As a patient approaches death, family members often are asked about their loved one’s preferences regarding treatment at the end of life. Advance care directives may provide information for families and surrogate decision makers; however, less than one-third of Americans have completed such documents. As the U.S. population continues to age, many surrogate decision makers likely will rely on other means to discern or interpret a loved one’s preferences. While many surrogates indicate that they have some knowledge of their loved (...) one’s preferences, how surrogates obtain such knowledge is not well understood. Additionally, although research indicates that the emotional burden of end-of-life decision making is diminished when surrogates have knowledge that a loved one’s preferences are honored, it remains unclear how surrogates come to know these preferences were carried out. The current study examined the ways that next of kin knew veterans’ end-of-life preferences, and their ways of knowing whether those preferences were honored in Veteran Affairs Medical Center inpatient settings. (shrink)

A series of papers in Philosophy, Ethics and Humanities in Medicine (PEHM) have recently disputed whether non-heart beating organ donors are alive and whether non-heart beating organ donation (NHBD) contravenes the dead donor rule. Several authors who argue that NHBD involves harvesting organs from live patients appeal to.

In The Ethics of Food, Gregory E. Pence brings together a collection of voices who share the view that the ethics of genetically modified food is among the most pressing societal questions of our time. This comprehensive collection addresses a broad range of subjects, including the meaning of food, moral analyses of vegetarianism and starvation, the safety and environmental risks of genetically modified food, issues of global food politics and the food industry, and the relationships among food, evolution, and human (...) history. (shrink)

Despite a heightened political discourse surrounding food choices, few studies have identified connections between political beliefs and consumer perceptions. Using gluten as an example, this article identifies how political opinions relate to opinions of food products. If an avoidance of gluten is a biological condition and not a social construct, there should be no correlation between political opinions and gluten avoidance. Our study uncovers a complex relationship between the social construction of gluten avoidance and the potential role of political views. (...) Perhaps most surprising, we find that supporters of Donald Trump are more likely to identify as avoiding gluten, relative to non-supporters. Findings suggest that future research might benefit from considering the political beliefs of consumers when estimating models of food demand. (shrink)

In spite of ethical analyses assimilating the palliative deactivation of pacemakers to commonly accepted withdrawings of life-sustaining therapy, many clinicians remain ethically uncomfortable with pacemaker deactivation at the end of life. Various reasons have been posited for this discomfort. Some cardiologists have suggested that reluctance to deactivate pacemakers may stem from a sense that the pacemaker has become part of the patient’s “self.” The authors suggest that Daniel Sulmasy is correct to contend that any such identification of the pacemaker is (...) misguided. The authors argue that clinicians uncomfortable with pacemaker deactivation are nevertheless correct to see it as incompatible with the traditional medical ethics of withdrawal of support. Traditional medical ethics is presently taken by many to sanction pacemaker deactivation when such deactivation honors the patient’s right to refuse treatment. The authors suggest that the right to refuse treatment applies to treatments involving ongoing physician agency. This right cannot underwrite patient demands that physicians reverse the effects of treatments previously administered, in which ongoing physician agency is no longer implicated. The permanently indwelling pacemaker is best seen as such a treatment. As such, its deactivation in the pacemaker-dependent patient is best seen not as withdrawal of support but as active ending of life. That being the case, clinicians adhering to the usual ethical analysis of withdrawal of support are correct to be uncomfortable with pacemaker deactivation at the end of life. (shrink)

Disfluencies include editing terms such as uh and um as well as repeats and revisions. Little is known about how disfluencies are processed, and there has been next to no research focused on the way that disfluencies affect structure-building operations during comprehension. We review major findings from both computational linguistics and psycholinguistics, and then we summarize the results of our own work which centers on how the parser behaves when it encounters a disfluency. We describe some new research showing that (...) information associated with misarticulated verbs lingers, and which adds to the large body of data on the critical influence of verb argument structures on sentence comprehension. The paper also presents a model of disfluency processing. The parser uses a Tree Adjoining Grammar to build phrase structure. In this approach, filled and unfilled pauses affect the timing of Substitution operations. Repairs and corrections are handled by a mechanism we term “Overlay,” which allows the parser to overwrite an undesired tree with the appropriate, correct tree. This model of disfluency processing highlights the need for the parser to sometimes coordinate the mechanisms that perform garden-path reanalysis with those that do disfluency repair. The research program as a whole demonstrates that it is possible to study disfluencies systematically and to learn how the parser handles filler material and mistakes. It also showcases the power of Tree Adjoining Grammars, a formalism developed by Aravind Joshi which has yielded results in many different areas of linguistics and cognitive science. (shrink)

Christiane Bailey | : Distinguant deux sens de « communauté morale », cet article soutient que certains animaux appartiennent à la communauté morale dans les deux sens : ils sont des patients moraux dignes de considération morale directe et équivalente, mais également des agents moraux au sens où ils sont capables de reconnaître, d’assumer et d’adresser aux autres des exigences minimales de bonne conduite et de savoir-vivre. Au moyen de la notion d’« attitudes réactives » développée par Peter F. (...) Strawson, je soutiens que les animaux sociaux qui sont à la fois objets et sujets d’attitudes réactives forment des communautés morales au second sens, dans la mesure où ils se traitent mutuellement comme des individus ayant des obligations et tenus à des exigences de bonne volonté minimale dans leurs interactions interpersonnelles. Distinguant l’agentivité morale du raisonnement moral, je soutiens que la capacité de raisonner abstraitement sur les principes et les conséquences de nos actions nous imposent plus de responsabilités que n’en ont d’autres animaux, mais que cela ne fait pas nécessairement de nous des agents moraux plus compétents que d’autres animaux sociaux. Je termine en donnant un aperçu de quelques implications de ce changement de perspective en éthique animale. | : This article draws the distinction between two meanings of “moral community” and maintains that certain animals belong to moral communities in both senses of the term: these animals are moral patients worthy of direct and equivalent moral consideration, but also moral agents in the sense that they are capable of recognizing and respecting minimal requirements of good conduct and manners as well as expecting and demanding the same from other members of their community. By way of the notion of “reactive attitudes” developed by Peter F. Strawson, I maintain that social animals who are at once objects and subjects of reactive attitudes constitute moral communities in the second sense of the term, in that they treat each other as individuals who have obligations and who are bound by the demand for a minimum of good-will in their interpersonal interactions. Distinguishing between moral agency and moral reasoning, I maintain that the capacity to reason abstractly about the principles and consequences of our actions gives us more responsibilities than other animals have, but that this does not necessarily make us more competent moral agents than other social animals. I conclude with an overview of some of the implications that this change in perspective has for animal ethics. (shrink)

Hoping to overcome the deficiencies of Bailey and Dewitt, and taking into account the insights of Diano, Kleve, and Merlan, Rist presents this book as an accurate and complete doxology of Epicurus’ philosophy. The book is written in a condensed style where doctrines treated early in the book are not fully explained until the completion of later parts. In trying to pin down Epicurus, distinct from the Epicureans, he depends heavily upon Lucretius and the few extant writings of Epicurus (...) himself, but he does range over the works of all the later students and commentators. Even so, much is left either vaguely outlined or problematic, and what is accepted from the more distant or biased sources is judiciously measured against the more accepted teachings. There are seven major chapters dealing with the canonic, physics, man and the cosmos, soul and mind and body, pleasure, friendship, and gods and religion. Certain of the teachings presented have a bearing, one upon the other, throughout the book and do much toward showing some consistency and richness to Epicurus’ philosophy: In the canonic, three types of criteria for judging as to the existence of a thing or the truth of a proposition are explained, viz., sensation, general concepts, and feeling. In the physics, a crucial topic is the role of the swerve with its logical priority. In the cosmos, there is the developmental, evolutionary character of the universe. In the soul and body of man, the animus/anima distinction is worked out. The interrelation of all these is brought to bear on the central theme of pleasure and the gods. Pleasure, as the stable condition of the flesh and confident expectation of the future on this score, with complete absence of pain and anxiety, involves the physics, friendship, the soul of man, and the canonic. Also important to his teaching on pleasure is the interplay of those pleasures based upon want and that pleasure which is a state of untroubledness. Rist makes good use of the teachings of the canonic to establish the existence of the gods. In describing their structure, he shows how the gods, as detached exemplars, fit in with the physics and canonic, and with the teaching on pleasure and friendship. He assiduously refrains from interpreting the role of the gods in Epicurus’ philosophy, but with their existence so presented future interpretations should be much enriched. This book is a superb piece of scholarship and an invaluable aid to the study of Greek philosophy.—W. A. F. (shrink)

Although modern texts of Propertius have generally inclined to conservatism, there remains a number of cases where editors have chosen, in Housman's phrase, timidly to alter what they might without rashness have defended; or where the arguments so far advanced in favour of the best attested reading leave room for supplement.Thus:I. 6. 25 f. me sine, quem semper uoluit fortuna iacere,hanc animam extremae reddere nequitiae.extrema … nequitia Fonteine.

Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

In a recent essay, Charles F. Capps takes issue with a permissive interpretation of St. Alphonsus Liguori’s influential understanding of cooperation with evil, and develops a more stringent interpretation. In response, I argue that Capps relies on a particular conception of what it is for a cooperator to share a wrongdoer’s bad intention, that this conception of intention sharing is not plausible because it is overly inclusive, and, that on account of this over-inclusiveness, it yields mistaken moral judgments. I then (...) develop and defend an alternative conception of intention sharing. (shrink)

R. Renehan's ingenious solutions to the problems of Symphosius 42. 1 and Anth. Lat. 207 in this journal , 471 f.) are much to be welcomed. On the other hand, I do not think that his defence of the manuscript reading in Anth. Lat. 24. 3 marcent post rorem violae, rosa perdit odorem holds water. Taking rorem as = rorem marinum he explains that ‘the poet is not presenting us with a piece of botanical information about the relative seasons of (...) the violet and rosemary; he means rather that all flowers wither and fade’. Actually, however, the poet on this showing does present information; and whether the information is botanically correct or not , that is an odd way to make his point. Stranger still is his choice of rosemary out of all the fading flowers of field and garden. It was bound to be I misunderstood. As Renehan indicates, ros = ros marinus is supported only by Virg. Georg. 2. 212–13, where the identity has been doubted, and Plin. HN 24. 100, where ex rore supra dicto refers back to ros marinum in 99. Renehan may well be the first reader not to take rorem as dew. And an evergeen shrub makes a singularly unfortunate illustration of floral decay, even though the shrub does produce a flower. Pliny classes it with herbs. (shrink)

oscula suspensis instabant carpere palmis oscula et alterna ferre supina fuga. It has been held that ferre is here to be taken for Φέρεσθαι oscula ferre is a fairly common phrase; I have met with it in twenty-two other passages down to Apuleius, in eighteen of which the meaning dare oscula is certain and in two more it is appropriate. The two exceptions are Ov. Her. 15. 101 non tecutn lacrimas, non oscula nostra tulisti and ibid 16. 253 f. oscula (...) si natae dederas, ego protinus ilia / Hermiones tenero laetus ab ore tuli. Neither offers a true parallel to the use attributed to Propertius , and in both the sense ‘bear away’ is made unmistakable by other words . As a matter of usage, then, it is justifiable to assume the meaning ‘give a kiss’ for this phrase, unless something else is plainly indicated. Further, the Propertian lines gain in point by the contrast between carpere ‘snatch’ and ferre ‘bring’. (shrink)

This dissertation develops and defends a detailed realist, internalist account of qualia which is consistent with physicalism and which does not resurrect the epistemological 'myth of the Given.' In doing so it stakes out a position in the sparsely populated middle ground between the two major opposing factions on the problem of phenomenal consciousness: between those who think we have a priori reasons to believe that qualia are irreducible to the physical , and those who implicitly or explicitly treat qualia (...) as contentful but non-phenomenal physical properties . ;I present a minimal, non-question-begging definition of "qualia" and then use this definition in a reformulation of the argument from perceiver relativity which shows that qualia must, at least in humans, be properties of states of the central nervous system. That is, brain states do not simply indicate the colours of external objects---they instantiate phenomenal colours. Since brain states are not coloured in the same way as are external objects, I argue that to token phenomenal property F must be to be the first-person phenomenal sensation of F. I build on this position to argue that the phenomenal apprehension of qualia, is "given"---immediate, certain and private---but that qualia nevertheless do not provide an absolutely certain epistemological foundation since they do not constitute a set of indisputable propositions about facts. I then define what it would be for physicalism to be true of qualia, but argue that the main a priori arguments for and against qualia physicalism---including the logical possibility of zombies and the impossibility of epiphenomenalism---fail. Whether qualia are consistent with physicalism, I claim, is still an open question, answerable only when we discover in more detail how qualia depend upon the brain. ;Although strongly in sympathy with many commonsensical intuitions about qualia, this account stands in contrast to most influential extant theories of qualia, such as eliminativism , externalism , or property-dualism : I conclude the dissertation by using its results to argue explicitly against these three positions. (shrink)

R. Renehan's ingenious solutions to the problems of Symphosius 42. 1 and Anth. Lat. 207 in this journal, 471 f.) are much to be welcomed. On the other hand, I do not think that his defence of the manuscript reading in Anth. Lat. 24. 3 marcent post rorem violae, rosa perdit odorem holds water. Taking rorem as = rorem marinum he explains that ‘the poet is not presenting us with a piece of botanical information about the relative seasons of the (...) violet and rosemary; he means rather that all flowers wither and fade’. Actually, however, the poet on this showing does present information; and whether the information is botanically correct or not, that is an odd way to make his point. Stranger still is his choice of rosemary out of all the fading flowers of field and garden. It was bound to be I misunderstood. As Renehan indicates, ros = ros marinus is supported only by Virg. Georg. 2. 212–13, where the identity has been doubted, and Plin. HN 24. 100, where ex rore supra dicto refers back to ros marinum in 99. Renehan may well be the first reader not to take rorem as dew. And an evergeen shrub makes a singularly unfortunate illustration of floral decay, even though the shrub does produce a flower. Pliny classes it with herbs. (shrink)

Anaxagoras’ theory of matter offers a problem which, in bald outline, may be stated as follows. The theory rests on two propositions which seem flatly to contradict one another. One is the principle of Homoeomereity: A natural substance such as a piece of gold, consists solely of parts which are like the whole and like one another—every one of them gold and nothing else. The other is: ‘There is a portion of everything in everything’, understood to mean that a piece (...) of gold , so far from containing nothing but gold, contains portions of every other substance in the world. Unless Anaxagoras was extremely muddleheaded, he cannot have propounded a theory which simply consists of this contradiction. One or the other proposition must be reinterpreted so as to bring them into harmony. Some critics attack one, some the other; some try to modify both. Mr. C. Bailey has recently published a fresh attempt to reconstruct the theory in a form consistent with itself. But the result, as he admits, is arbitrary and uneconomical. These defects, like all the contradictions and obscurities found in other accounts of the system, can be traced to the second proposition: ‘There is a portion of everything in everything’, or rather to the construction put upon it. The language is crude, vague, and ambiguous. What does ‘everything’ mean? Has the first ‘everything’ the same sense as the second ? If taken to mean that there is a portion of every material substance in every material substance, the proposition leads to a result for which ‘uneconomical’ is an indulgent epithet. (shrink)

The present essay is intended to supply amplification, and where necessary correction, to my previous article on Anaxagoras' philosophy. Since its publication important essays on the same subject have been written by Mr. Cyril Bailey and by Mr. F. M. Cornford, and the present essay is also an attempt to examine some of the theories put forward in them. There are one or two points which may be stated at the outset. The conclusions which I put forward five years (...) ago I still believe to be valid. Some of the presentation of the evidence, however, I now see to be misleading and inadequate, notably the treatment of Aristotle's evidence, which I now hope to deal with more fully, and to show that it lends even stronger support to my thesis. I should also say that my former use of ‘Elements’ as a convenient collective term to refer to the four Empedoclean Elements has proved confusing, since it was never intended to suggest that these substances were elements in Anaxagoras' system. I now refer to them by their names in full. (shrink)

This useful anthology comprises seventy-nine selections arranged under three headings. Part I is titled "Ancient and Classical Ideas of Space"; part II, "The Classical and Ancient Concepts of Time"; part III, "Modern Views of Space and Time and their Anticipations." According to the general editors of the Boston series, R. S. Cohen and Marx W. Wartofsky, Capek’s choice of contents was governed by the desire to show that "parts of our view of nature greatly and mutually influence other parts, and (...) that our conception of the world keeps evolving. Thus, ideas of time intertwine with ideas of space, and both with ideas of matter and force." F. M. Cornford’s essays, "The Invention of Space" and "The Elimination of Time by Parmenides," introduce parts I and II respectively. In part I, while Descartes, Pascal, Gassendi, Newton, etc., speak for themselves, the ancients and medievals are given other mouthpieces—Duhem’s monumental Le système du monde, for Plato, Aristotle, and the medievals; C. Bailey, for Leucippus, Epicurus and Lucretius; Koyré, Höffding, Jammer, for the period from Bradwardine to William Gilbert. On the subject of time, however, both ancient and classical authors are allowed to express their opinions in their own words, with the understandable exception of the Stoics. Part III begins with the prerelativistic critique of Newton as well as the well-known Clarke-Leibniz discussion on the nature of space and time. This third part, however, is dominated largely by the implications of Einstein’s general and special relativity theories. For instance, we have Minkowski’s "Union of Space and Time." Four items, at least, are devoted to the twin-paradox. Some argue for a static, subjective, or even idealistic conception of space-time whereas positivists like Frank attack Sir James Jeans’ and other idealistic interpretations of relativity as instances of meaningless metaphysics. Part III concludes with Weyl’s objectivistic interpretation of quantum-mechanical indeterminacy. While it is difficult to find an anthology that will please all readers or teachers, this work goes far towards dealing comprehensively with the subject of space and time. As Cohen and Wartofsky note, what is distinctive of Capek’s approach within the field of philosophy of nature and its history is that "he is greatly appreciative of Bergson, James, Peirce and Whitehead" and though influenced by them, he is also critical because of the "understanding of the philosophical import that contemporary physics brings into our picture of the world." In a lengthy introduction, the editor explains his rationale for each item he includes. In general this is very helpful, but in some instances the suggested historical connections are misleading at best, if not simply false or questionable. Einstein for instance is said to have "rejected any absolute frame of reference which would be a substrate of absolutely simultaneous events... within the context of Michelson’s vain search for the absolute motion of the earth." This seems to imply—as many others have claimed—that the negative results of the ether-drift experiment influenced Einstein in formulating his relativity theory, whereas historians have pointed out that if Einstein referred to the experiment, it would have to be as a confirmation of his theory, since he did not learn of the results obtained by Michelson and Morley until after the publication of his revolutionary paper in 1905. Though there are other generalizations in the introduction which might be open to dispute, Capek’s prefatory remarks are in general helpful, and the essay collection as a whole stands on its own feet. It is valuable, if for no other reason, that a number of the selections appear in English translation for the first time.—A.B.W. (shrink)

Some philosopheis (e.g. Ayer, Reichenbach, Lewis) use a version of the argument from illusion to prove that empirical statements are never certain. But this argument, unwittingly, also calls into doubt the certainty of calculations in logic and mathematics. The argument seems to call into question the application of any rule on the grounds that one might at some future time find out that one had misapplied it. But the argument from illusion is only the illusion of an argument.

It is almost universally accepted that traditional provider-patient relationships should be governed, at least in part, by the ethical principles set forth by Beauchamp and Childress. These principles include autonomy, beneficence, non-maleficence and justice. Recently, however, the nature of medial practice has changed. The pervasive presence of computer technology in medicine raises interesting ethical questions. In this paper we argue that some software designers should be considered health care providers and thus be subject the ethical principles incumbent upon “traditional” providers. (...) We argue that these ethical responsibilities should be applied explicitly rather than as a passive, implicit, set of guidelines. (shrink)